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Molecular Biology: Principles of Genome Function, by Nancy Craig, Rachel Green, Carol Greider, Gisela Storz, Cynthia Wolberger, Orna Cohen
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The biological world operates on a multitude of scales - from molecules to tissues to organisms to ecosystems. Throughout these myriad levels runs a common thread: the communication and onward passage of information, from cell to cell, from organism to organism and ultimately, from generation to generation. But how does this information come alive to govern the processes that constitute life? The answer lies in the molecular components that cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology.
Molecular Biology: Principles of Genome Function, Second Edition, offers a fresh approach to the teaching of molecular biology by focusing on the commonalities that exist between the three kingdoms of life, and discussing the differences between the three kingdoms to offer instructive insights into molecular processes and components. This gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity. Additionally, an integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics
As an experimental science, molecular biology requires an appreciation for the approaches taken to yield the information from which concepts and principles are deduced. Experimental Approach panels throughout the text describe research that has been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Molecular Biology further enriches the learning experience with full-color artwork, end-of-chapter questions and summaries, suggested further readings grouped by topic, and an extensive glossary of key terms.
Features:
A focus on the underlying principles of molecular biology equips students with a robust conceptual framework on which to build their knowledge
An emphasis on their commonalities reflects the processes and components that exist between bacteria, archae, and eukaryotes
Experimental Approach panels demonstrate the importance of experimental evidence by describing research that has been particularly valuable in the field
- Sales Rank: #201489 in Books
- Published on: 2014-06-10
- Original language: English
- Number of items: 1
- Dimensions: 8.00" h x 1.50" w x 10.90" l,
- Binding: Hardcover
- 936 pages
Review
Review from previous edition While I rarely make textbooks the core of my teaching material, the general presentation of material and interleaving of research results and methods is very similar to my preferred teaching strategy. That is what led me to adopt this remarkable textbook for use in my class. Richard S. Myers, University of Miami I believe the strengths of the text are the organization and layout, with simple diagrams & headings that make mental organization easier for the students. Julia Frugoli, Clemson University I am delighted with Molecular Biology: Principles of Genome Function. It explains material extremely well. It has a nice balance of detail and focus on understanding the overall process. It is fantastically up to date. Barbara C. Hoopes, Colgate University - Hamilton, NY I would highly recommend this book to any colleague who was considering instituting a basic class in molecular biology. Andrew J. Andres, University of Nevada - Las Vegas
About the Author
Nancy L Craig is Professor and Howard Hughes Medical Institute Investigator at the Johns Hopkins University School of Medicine. She is a recipient of the Johns Hopkins University Alumni Association Excellence in Teaching Award, as well as a Fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science, and a member of the National Academy of Sciences.
Orna Cohen-Fix is a Senior Investigator at the National Institute of Diabetes and Digestive and Kidney Diseases, Adjunct Professor at Johns Hopkins University, and the Co-Director of the NIH/Johns Hopkins University Graduate Partnership Program. She is the recipient of a Presidential Early Career Award for Scientists and Engineers and an Association of Women in Science Mentoring Award for her work on promoting the retention of women in science.
Rachel Green is Professor of Molecular Biology and Genetics at and Howard Hughes Medical Institute Investigator the Johns Hopkins University School of Medicine, and a member of the National Academy of Sciences. She is the recipient of a Johns Hopkins University School of Medicine Graduate Teaching Award.
Nobel Laureate Carol Greider is Professor and Director of the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine. She is a member of the National Academy of Sciences and is the recipient of numerous awards, including the Gairdner Foundation International Award, the Louisa Gross Horwitz Prize, and the Lasker Award for Basic Medical Research. In 2009, she was awarded the Nobel Prize in Physiology or Medicine together with Elizabeth Blackburn and Jack Szostak for the discovery of telomerase.
Gisela Storz is a Senior Investigator at the National Institute of Child Health and Human Development. She is a Fellow of the American Academy of Microbiology, American Academy of Arts and Sciences, and National Academy of Sciences, and a recipient of the American Society for Microbiology Eli Lilly Award.
Cynthia Wolberger is Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine. She is a Fellow of the American Association for the Advancement of Science and a recipient of the Dorothy Crowfoot Hodgkin Award of the Protein Society.
Most helpful customer reviews
15 of 15 people found the following review helpful.
An awesome "central dogma" book.
By Gavin Scott
I'm comparing this book (MB) to Molecular Biology of the Cell (MBoC), which is probably my favorite textbook of all time.
This one (MB) is not as much of a general cell biology book as it primarily covers only the elements of the so-called "central dogma" of molecular biology. DNA replication and transcription into RNA, and RNA translation into protein, plus all the regulatory aspects of those processes (as well as chapters on the cell cycle, DNA repair, transposable elements, and genomics), unlike MBoC which spends more or less the first half of the book on those topics and then devotes the second half to the further biology of the Cell, covering things like membranes, energy conversion, cell signalling, cancer, and the immune system.
Both books do a good job of introducing the Biochemistry you need in order to understand what follows. MB has a great first chapter that gives an overview of the book (basically "Molecular Biology in 30 pages").
Where MB shines though is in its more in-depth coverage of the topics it touches on. It devotes about twice as many pages to these topics as the current edition of MBoC does. MB is also wonderfully illustrated and does a good job of visually explaining things. MB contains lots of "experimental" panels that talk about how various aspects of the cell were discovered.
Both books include chapters on techniques for manipulating the genetic material in cells. I thought the current edition of MBoC felt slightly more up to date, but both books are very current editions with a good overview of the current state of the art.
Both books are quite readable. I would give the edge to MBoC here in terms of ease of reading as MB seems just a bit denser to me. But both are very easily understandable.
I can highly recommend this book (MB) to anyone looking for an in-depth coverage of the central themes of molecular biology (how DNA and genes work). It goes pretty deep for a first course, but it does not presume much of any background knowledge so it would be an appropriate book to introduce someone to the subject who wants to understand things very thoroughly.
If I had to choose only one or the other I'd still prefer the new MBoC edition due to its much broader coverage of cell biology (it's also 50% larger and twice as expensive though), but this one is really excellent at what it covers. I bought it after previewing the "Look Inside" pages and I have not been disappointed.
If the mechanics of the functioning of cells interests you then you'll probably be fascinated and really enjoy the depth of knowledge you gain from this book, and it's something you'll want to keep and probably use frequently as a reference if you progress further in the study of biology. If you find the details tedious, then this one might be more depth than you want, and something like Essential Cell Biology, 4th Edition might serve you better.
Currently this book is not available as a Kindle "Print Replica" e-textbook yet, where the other titles mentioned here are.
Really happy with the book, easily a 5+ star experience.
G.
4 of 5 people found the following review helpful.
Excellent illustrations/case studies to help clarify more difficult points
By Suzanne Jacobs
Though review of genome function to include current available information re: RNAi, CRISPR, etc. Excellent illustrations/case studies to help clarify more difficult points. Excellent terminology and index. Will be kept as reference for anticipated studies with the understanding that information changes and expands daily but the basic information will remain the same.
4 of 5 people found the following review helpful.
Best molecular biology book out there...
By G. Miller Jr. MD
Clearly written! Complete and well organized. Develops a foundation and then more complex concepts. Authors did a great job!
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